Incidental findings in biomedical research

June 16, 2015

Investigations such as genome sequencing and brain imaging have the potential to reveal details about the patient of research subject which were not the principal reason for the study. The ethical issues associated with such “incidental findings” is the subject of this short film, made by students at the University of Leicester.

The video was rated the third best produced by students in the 2014-15 cohort.

People interested in knowing more about the topic might also like to read:
Green et al. (2013) ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing Genetics in Medicine 15:565-574

Vernooji et al. (2007) Incidental Findings on Brain MRI in the General Population New England Journal of Medicine 357:1821-1828


Direct to Consumer Genetic Testing

June 12, 2013
The Nuffield Council on Bioethics report about Personalised Healthcare includes consideration of DTC Genetic Testing

The Nuffield Council on Bioethics report about Personalised Healthcare includes consideration of DTC Genetic Testing

The fall in the cost of DNA sequencing has opened the door to providing an individual with genetic information on such issues as paternity and the risk of developing or passing on a particular genetic disease. Some services are available via formal channels, but there is also a burgeoning market in direct-to-consumer (DTC) sales of genetic information and the associated interpretation of that data.

This video, made by second year students at the University of Leicester, looks at some of the ethical issues arising from the availability of personal genetic data direct from commercial companies.

The following link offer more details about: Teaching resources using the Nuffield report on medical profiling

You may also be interested in the post Is there a gene for oversimplistic analysis? from our sister site Journal of the Left-handed Biochemist.


Personalised Healthcare

May 19, 2011

This is the 4th resource produced by Nuffield's education team to accompany their more chunky reports on ethical developments in biology and medicine

The latest in a series of educational resources to accompany major reports by the Nuffield Council on Bioethics are now available. Picking up from the 2010 Nuffield report on the ethics of Personalised Healthcare, the resources have been developed by the Reaching Out to Young People team. The materials are based around three case studies looking at the impact of different developments moving medicine away from the traditional patient-doctor consultation. These are: the availability of personal genetic profiles; the ability to buy medicines online; and the rise of the internet as a source of health information.

The story of Christina and her decision about whether or not to buy a test for an inherited disease is one of the new resources

(Note: anyone who has ended at this post looking for “personalised healthcare” in the pharmacogenetic sense might like to know that this was the subject of a different Nuffield report in 2003 and hence it was not included in the 2010 document).


Interactive tutorials on genetics and ethics at the PHG Foundation

May 19, 2011

Here’s a useful resource for teaching about bioethics and the ethical implications of new developments in genetics. The PHG Foundation website has a large number of tutorials and other educational activities on these topics. You need to register with the site to see them, but there is no fee and the “cost” of registration seems only to be a periodic e-mail newsletter also containing helpful updates.

The PHG Foundation grew out from the Public Health Genetics unit

If I understand correctly funding for the educational developments at PHG has come and gone so nothing new will be appearing in that section of their site – but the stuff that’s already there is definitely worth a look.

The tutorial on moral theories is just one of the bioethics-related resources on the PHG Foundation site


Human Genome Project: 10 years on

July 1, 2010

The tenth anniversary of the announcement that the human genome had been  ‘completely’ sequenced, has led to a large number of programmes and publications reflecting upon the impact that this information is having upon biomedicine. On 24th June, Today, the flagship current affairs programme on UK Radio 4, included a very interesting interview with John Sulston and Francis Collins the men who, respectively, had headed up the UK and USA ends of the publicly-funded consortia. The interview (7 minutes) can be heard via this link, and a transcript can be found here.


Darwin’s Dangerous Idea – Born Equal? (BBC2)

March 25, 2009
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This episode of Darwin's Dangerous Idea can be viewed online via the BBC iPlayer until April7 2009.

In the three-part series, Darwin’s Dangerous Idea, broadcast on BBC2 to mark the 200th anniversary of the birth of Charles Darwin and the 150th anniversary of the publication of On the Origin of Species, broadcaster Andrew Marr explores the impact of the theory of evolution by natural selection on science, politics and society.

While the first and third episodes, respectively entitled Body and Soul and Life and Death, explore the historical spread of Darwin’s theory and the way it can be employed within conservation and ecology, the second episode, Born Equal?, includes a short section (between 00:45:12 and 00:56:20) that could be used in bioethics teaching.

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The Daily Politics Show – “Should we be more wary of genetic screening?”

February 9, 2009
Watch this edition of The Daily Politics Show via BBC iPlayer (freely available until February 10th 2009)

The Daily Politics Show

The edition of The Daily Politics Show broadcast on BBC2 on February 3rd 2009 contained an item on the use of embryo screening during IVF (see 00:15:42 to 00:22:25). The section begins with a short explanatory VT, which covers the technique of prenatal genetic diagnosis – PGD – and its uses in IVF, and some of the main ethical positions. The programme’s hosts – Andew Neil and Sangita Myska – then discuss the ethical implications of genetic screening and embryo selection with Professor Robert Winston. This short post summaries the main bioethical arguments put forward in this 7 minute clip, and suggests how it may be used in teaching.

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